The pair will join new head coach John Paddock's staff.
The 57-year-old Low is a former head coach of the Edmonton Oilers and New York Rangers who has been with the Senators for four seasons. He previously worked as a goaltending coach and pro scout for the Sens.
Low has more than 30 years of professional hockey experience as both a coach and player. The native of Birtle, Man., played 11 NHL seasons as a goaltender.
Wilson most recently worked with the Western Hockey League's Medicine Hat Tigers. He has previously served as the personal coach to Senators No. 1 goalie Ray Emery, among many others.